![]() The 2021 freeze suggests a need to rethink the state’s regulatory approach to energy to avoid future such outcomes. The gap between production and demand forced the non-profit grid manager, the Electric Reliability Council of Texas (ERCOT), to cut off supply to millions of customers or face a systems collapse that by some accounts was minutes away. Overall, the state faced outages of 30 GW of electricity as demand reached unprecedented highs. Feedback between failures in the two systems made the situation worse. ![]() Texas failed to sufficiently winterize its electricity and gas systems after 2011. This piece offers a retrospective on what caused the blackouts and the knock-on effects on other services, the subsequent financial and political effects of the freeze, and the implications for Texas and the country going forward. In the wake of the freeze, there has been major fallout among regulators and utilities as actors sought to apportion blame and utilities and generators began to settle up accounts. Economic losses from lost output and damage are estimated to be $130 billion in Texas alone. ![]() The freeze had cascading effects on other services reliant upon electricity including drinking water treatment and medical services. The Texas freeze of February 2021 left more than 4.5 million customers (more than 10 million people) without electricity at its peak, some for several days.
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![]() Even if you don’t dislike your job, you’re probably not getting all the mental health vitamins, so to speak, out of your job. “These are things that are crucial to mental wellbeing in general, but they’re not things that we get a lot of in our daily activities. “We know that games are exceptionally good at helping us feel like our decisions matter, and that we can have power over the world around us and that we can have a sense of accomplishment,” says Dunlap, who is based in Rockville, Maryland. Kelli Dunlap, a clinical psychologist who has a master’s in game design, says video games can help people living with mental illness by providing a way to relax, connect with others and feel competent. Kelli Dunlap (Photo courtesy of Kelli Dunlap) Those include Hellblade: Senua’s Journey, whose main character struggles with psychosis Celeste, about the quest of a girl who has anxiety to climb a mountain and Psychonauts, about a boy who projects himself into other people’s mental worlds and helps them fight their demons. But even before the pandemic, researchers have cited the benefits of gaming on mental health, and game creators have in recent years begun portraying mental illness in games in more thoughtful and less stigmatizing ways than in the past. Those findings are particularly resonant as people worldwide mark Mental Health Awareness Month this May, some 16 months into the pandemic. The study found that 84% of respondents agreed gaming has positively impacted their mental health over the past year, while 71% said gaming helped them feel less isolated. A recent Microsoft study within the Xbox Research Accessibility Community Feedback Program, a group made up of players with disabilities, looked at gaming and mental health during the pandemic. Like many people worldwide, Kieswetter has turned to gaming to cope with the isolation and anxiety of the past year. They have been there for me, and I’m there for them.” The friends I have made over the years are so incredibly supportive and I consider them family. “Gaming has had a huge impact on me as far as my mental health. ![]() “Gaming gets your mind off things for a little while, and that helps,” says Kieswetter, who lives in Ontario, Canada. Many of them reached out to offer support. When he felt up to it, Kieswetter would play games, and sometimes he’d talk with his gamer friends about what he was going through. ![]() When Kieswetter’s sister died unexpectedly almost a decade ago from complications following a surgery, gaming provided a refuge from his overwhelming grief and sadness. Kieswetter is now an Xbox Ambassador who loves helping other gamers. Gaming was a community, and gamers were his people. He enjoyed playing with friends and meeting new friends through gaming. Kieswetter kept playing into adulthood and became even more passionate about gaming. As a child, John Kieswetter played video games with his younger sister and two cousins who lived nearby as often as he could. ![]() The outdoor pool complex is ideal for exercise and relaxation. As an extra convenience, bathrooms provide cosmetic products.The sports and entertainment facilities at the complex ensure that guests have plenty of activities to choose from during their stay. A telephone, a flatscreen television and WiFi (no extra charge) are provided as well. An ironing set is provided for guests' convenience. Guests will also find a microwave included among the standard features. Valuables can be securely stored in a safe. Daily newspapers are available for purchase.Guests have a choice of 156 non-smoking rooms. Wireless internet access is provided in public areas (no extra charge). Services and facilities include a baggage storage service, a TV room, a library, a transfer service, a coin-operated laundry, a roof terrace and a lounge. The hotel is within walking distance of shops, entertainment, nightlife and regular ferries to Valletta.The friendly staff at the reception desk in the lobby are happy to answer any questions. Business, Other Amenities Featured amenities include complimentary newspapers in the lobby, luggage storage, and laundry facilities.Ĭonveniently located on Sliema Seafront, this hotel provides top quality accommodation in the centre of Malta, easily accessible by all public transport from across the island making it much easier for our guests to commute throughout their stay. A complimentary continental breakfast is served daily from 7:30 AM to 9:30 AM. Quench your thirst with your favorite drink at the bar/lounge. Dining Satisfy your appetite at the bed & breakfast's coffee shop/café. Amenities Enjoy recreation amenities such as an outdoor pool or take in the view from a terrace. Conveniences include safes and desks, and housekeeping is provided daily. ![]() Private bathrooms with bathtubs or showers feature complimentary toiletries and hair dryers. Complimentary wireless Internet access is available to keep you connected. Rooms Make yourself at home in one of the 12 air-conditioned rooms featuring refrigerators and flat-screen televisions. This bed & breakfast is 6 mi (9.7 km) from Mediterranean Conference Centre and 6.5 mi (10.5 km) from Mnajdra Megalithic Temples. If you are using the Omio app to search for flights between Bremen and Valletta, you can check straight away if the KLM ticket is a mobile ticket, which makes it easy for you to go paperless when traveling without needing to purchase tickets in person at the airport.Property Location Located in Gudja, Talbot and Bons Boutique Bed & Breakfast is within a 15-minute drive of Blue Grotto and Hagar Qim. You can expect to travel 1216 miles (1961 km) from Bremen to Valletta on a flight with KLM. Omio helps you find the ideal KLM flight from Bremen to Valletta by showing you KLM current flight schedules and timetables, the plane tickets on offer (including amenities offered onboard and travel information like baggage allowance) and the best prices for this Bremen to Valletta journey. One of the best ways to travel to Valletta from Bremen is by taking a flight with KLM. ![]() KLM is the Netherlands' national carrier and offers two types of ticket for your flight from Bremen to Valletta: Economy and Business. Lufthansa from Bremen to Valletta flight information: You can then sit back and enjoy the 1216 miles (1961 km) route to Valletta from Bremen with ease and comfort on a flight with Lufthansa. Once you find your ideal route, book your one-way flight to Valletta from Bremen on Omio or in the Omio app in just a few simple steps. If you search for Lufthansa tickets in the Omio app, you can also see if they are mobile tickets so that you can travel paperless rather than needing to wait in a line at the airport in person to purchase tickets. Fly between Bremen and Valletta and book your most convinient flight ticket from Lufthansa's many ticket options including: Economy Light, Economy Classic, Economy Flex, Business Class and First Class.Įnjoy a smooth and easy trip from Bremen to Valletta with Lufthansa! As an official travel partner of Lufthansa, Omio can help you search current flight schedules and timetables from Lufthansa, compare the best routes between Bremen and Valletta as well as the class fares available for this route (including information on baggage allowance and amenities provided onboard), and buy the most affordable Lufthansa Bremen to Valletta plane ticket available today. ![]() Importantly, genetic ablation or functional peptide blocking of DPEP1 significantly reduced neutrophil recruitment to the lungs and liver and provided improved survival in models of endotoxemia. Using biochemical, genetic, and confocal intravital imaging approaches, we identified dipeptidase-1 (DPEP1) as the target and established its role as a physical adhesion receptor for neutrophil sequestration independent of its enzymatic activity. Exploiting an unbiased in vivo functional screen, we identified a lung and liver homing peptide that functionally abrogates neutrophil recruitment to these organs. Although selectins and integrins mediate recruitment in many tissues, they have a minimal role in the lungs and liver. These observations expand our understanding of the Th1-Th2 paradigm during infection.Ī hallmark feature of inflammation is the orchestrated recruitment of neutrophils from the bloodstream into inflamed tissue. Surprisingly, STAT6 did not enhance intracellular parasite proliferation, but rather modulated the size and permissiveness of the monocytic host cell reservoir via regulation of IFN-γ and IL-10. Monocytes were required for early parasite expansion and acquired an alternatively activated phenotype despite the Th1 dermal environment required for their recruitment. During early Leishmania infection of the skin, IFN-γ- or STAT6-mediated changes in phagocyte activation were counteracted by changes in IFN-γ-mediated recruitment of permissive CCR2 + monocytes. We report that prior to influencing activation, Th1/Th2 immunity first controls the size of the permissive host cell reservoir. However, observations in multiple infectious settings demonstrate deficiencies in mediators of Th1-Th2 immunity, which have paradoxical or no impact. The impact of T helper (Th) 1 versus Th2 immunity on intracellular infections is attributed to classical versus alternative activation of macrophages leading to resistance or susceptibility. Herein, we have identified a series of peptides with utility as an innovative platform to assist in targeting glioblastoma for the purpose of diagnostic or prognostic imaging, image-guided surgery, and/or improved delivery of therapeutic agents to glioblastoma cells implicated in disease relapse. Simultaneous use of five independent targeting peptides provided greater coverage of this complex tumor and selected peptides have the capacity to deliver a therapeutic cargo (oncolytic virus VSVΔM51) to the tumor cells in vivo. Cargo-conjugated peptides delivered contrast-enhancing agents to highly infiltrative tumor populations in intracranial xenograft models without the obvious need for blood brain barrier disruption. Candidate peptides were screened for specificity and ability to target glioblastoma cells in vivo. To accomplish this, a combinatorial phage display library was biopanned against glioblastoma cell model systems that accurately recapitulate the intra- and inter-tumor heterogeneity and infiltrative nature of the disease. The goal of this study was to target the invasive and stem-like glioblastoma cells that evade first-line treatments using agents capable of delivering imaging enhancers or biotherapeutic cargo. Clinical progress is hampered by the inability to detect and target glioblastoma disease reservoirs based on a diffuse invasive pattern and the presence of molecular and phenotypic heterogeneity. Little improvement is seen with standard surgery, radiotherapy and chemotherapy. In a disease context, influenza A virus infection impaired AM crawling via the type II interferon signaling pathway, and this greatly increased secondary bacterial co-infection.ĭespite extensive molecular characterization, human glioblastoma remains a fatal disease with survival rates measured in months. Impairing AM chemotaxis toward bacteria induced superfluous neutrophil recruitment, leading to inappropriate inflammation and injury. Importantly, these macrophages sensed, chemotaxed, and, with high efficiency, phagocytosed inhaled bacterial pathogens such as P. aeruginosa and S. aureus, cloaking the bacteria from neutrophils. ![]() Developing in vivo real-time intravital imaging of alveoli revealed AMs crawling in and between alveoli using the pores of Kohn. ![]() However, this would translate to omnipresent persistent inflammation. If AMs, like most tissue macrophages, are sessile, then this numerical advantage would be exploited by pathogens unless neutrophils from the blood stream intervened. Interestingly, alveoli outnumber alveolar macrophages (AMs), which favors alveoli devoid of AMs. During respiration, humans breathe in more than 10,000 liters of non-sterile air daily, allowing some pathogens access to alveoli. ![]() This also includes being angry or stubborn and overthinking. When you get jealous because of your partner- your husband or boyfriend, best friend, not giving you attention, is called cute jealously. Territorial is protecting what’s already yours.Ĭute jealousy quotes tell that you are cute when you are jealous. Jealous is when you want something that’s not yours. If your best friend is not jealous of your other friends, you don’t have a bestie.The jealousy and envy quotes will motivate you to convert this dangerous element into something fruitful and rational! You will feel much better and productive too. If you are looking forward to getting rid of this bad quality or using it to transform your life into something positive, read through these wise jealousy quotes! You need to control jealousy by reading these jealousy quotes because this can take a strong grip on you and prove to be more harmful to yourself than others. The element of jealousy can keep growing, and it is a natural phenomenon, but did you know you could transform yourself from this bad quality? Jealousy has various emotions attached to it love, the quest to do better, and anger. Jealousy is not a healthy quality, and it is not a feeling which you can control. Are you looking for jealousy quotes and quotes for envy to get transformed?ĭo you ever find yourself envying someone who has more than you? Sometimes you can be jealous of someone because they are better than you in ways you struggle to be. ![]() ![]() isolation of the leading derivative and pivoting, differential substitution, and linear integrability conditions).ĭifferential consequences are enforced by the spawning (differentiation with respect to each independent variable) of each equation, which naturally results in leading linear equations.īefore algorithm completion, rifsimp forms an algebraic Groebner basis over the leading nonlinear equations, spawning any new relations that appear as a result of S-polynomials. If leading linear equations with usable pivots are found in the algebraically simplified set, rifsimp removes them from the set, and treats them using leading linear methods (i.e. This can increase the number of cases in the output, but is required for the proper functioning of the more compact nonlinear equation handling algorithm, so if this splitting is not desired, pure Groebner basis methods can be used instead with the grobonly option. If there was no condition on u x + u, then rifsimp would split into the cases u x + u ≠ 0 and u x + u = 0. So for the example above, the initial is u x + u. ![]() This coefficient is called the initial of the equation. Note: during the course of the algorithm, when nonlinear equations are encountered, case splitting is performed on the coefficient of the highest degree of the leading derivative each equation. This is simply chosen to be pure lexicographical ordering with respect to the ordering imposed on the linear derivatives.įor example, the equation u xx 2 u x + u xx 2 u − u x 2 − u 2 for a system in which u x + u ≠ 0 holds is algebraically solved for u xx 2 giving the nonlinear relation: u xx 2 = u 2 + u x 2 u x + u. In order to perform the algebraic simplification of these nonlinear equations, a monomial ordering must be imposed for all possible nonlinear terms. Use of this set of equations allows recognition of, and elimination of redundant equations, and produces a more compact representation (due to the use of pivots and lack of S-polynomials). This simplification process resembles an algebraic Groebner basis, but takes the inequations (pivots) of the system into account, and does not compute algebraic S-polynomials. Conversely, the equation u tt 2 − u t = 0 is leading nonlinear, and is always handled through the nonlinear methods described here.ĭuring the course of the computation, nonlinear equations are always differentially simplified with respect to the linear equations of the system, but they are also algebraically simplified with respect to each other. This equation is linear in its leading indeterminate, so as long as u can be present in a pivot it will be handled through case splitting rather than nonlinear equation handling (see rifsimp ). This help page explains how rifsimp handles equations which are polynomially nonlinear in their leading indeterminate (called leading nonlinear equations), or equations that are leading linear, but have a coefficient that depends on pivot restricted variables (see nopiv in rifsimp ).Īs an example, consider the equation u tt u − u t 2 = 0. Information and options specific to nonlinear equations ![]() Like the rest of the live music industry, Elsewhere shut its physical doors in March. The potential of Twitch excited Elsewhere’s team as virtual communication became de rigueur. Other features Elsewhere is working on involve opportunities for voting, guest call-ins, and even ways for the audience to take control of the camera during a stream. Twitch’s graphic chat features allow Elsewhere’s Sound Space attendees to have an active voice, either by sending messages filled with channel-custom emojis or through “ bits,” tiny tips for a channel. ![]() The sound design and augmented reality effects will also attempt to push the performance into a more immersive experience. Elsewhere’s team developed effects and animation through TouchDesigner and Aximmetry especially for the upcoming shows to provide 2- and (somehow) 3-D video effects. Twitch’s open API allows for experimentation, creativity, and play unlike any other streaming services. “By reopening their doors to a virtual audience, Elsewhere is breathing new life into Brooklyn’s independent music scene, giving fans a space to connect while taking part in this cultural experience and supporting their favorite local venue.”Īlong with the live performances, the audience will have opportunities to interaction-in theory with more than a comment or emoji. “Elsewhere is known as a risk taker, booking eclectic and highly curated artists and building scenes from the ground up,” says Brian Rucker, director of premium music content at Twitch. Sound Space’s variety format and intergalactic theme-“the sci-fi misadventures of a music deity marooned in space, and their curious cultural dispatches back to Earth”-is a riff on the technological foibles that have become integral to pandemic life. New York rapper Princess Nokia headlines January’s show, which is free. “Our effort will be to go deeper and deeper and to make that a two-way street.”Įvery month starting next Thursday, host Peter Smith will lead audiences through an interactive variety show consisting of comedy, live music, and artist interviews. “The magic of Twitch is that feeling that you can reach into the screen and poke the talent on the screen and they will respond, in one way or another,” says Sound Space’s Technical Director Noah Norman. Enter Twitch, the massively popular live-streaming platform, owned by Amazon: “Elsewhere’s Sound Space,” the club’s new monthly virtual experiment, will debut on Jan. The club aspires to redefine and augment the virtual live music experience for audiences in ways that could possibly even outlive the coronavirus. The screen forms an impossible barrier between artist and audience, rendering all interactions as flat as the two dimensional display.Įlsewhere, the three-year-old indie nightclub and music venue in Bushwick, wants to change that by making its events truly interactive. Its replacement, the livestream, is an imperfect substitute. For the foreseeable future, live music is but a post-pandemic pipe dream. The information on this screen is all drawn from your record in the system. You will be asked to enter in your new password twice to ensure that you do not make a mistake. Once you receive the email, click the link. The email that you receive will contain a unique link to reset your password. If a matching account with an email address is found, you will soon receive an email at that address with further instructions for resetting your password. Your barcode or user name has been submitted for a password reset. You will be taken to a page that displays the following message: If you do not have a valid email address in your account, you will not be able to receive the email to reset your password.Ĭlick Submit to send the password reset request. Note: Your library account should have a valid and active email account associated with it. ![]() If you enter your library card number, leave out the spaces. The number that appears on your library card or on your mini-card has spaces in it. If you're still having trouble, adding to a list of trusted sites may solve this problem.Įnter your library card number OR user name. After enabling cookies, try to login in again. You will need to ensure cookies are enabled in your browser. Sometimes the internet security settings on a computer will prevent successful login. This can be resolved at your local library. Patron accounts can become blocked or barred for a variety of reasons. Sometimes a library card expires, and the patron is not aware of it. If you don’t know it, you can get it from your local librarian. Your library card has an expiration date. This can be remedied by contacting your local library or by using the "Forgot your password" link. Occasionally, a patron’s password in incorrectly changed at the local library. Contact your local library if you do not know your barcode or user name. If you have multiple cards, perhaps the number you are using is inactive. Įnsure you are entering the correct barcode without any spaces. If you are still having trouble, contact your local library. If you have forgotten your password, click "Forgot Your P assword?". Mis-typed or incorrect user name or password Here is a list of common reasons why you might not be able to log into your account successfully: Why am I having trouble getting into My Account? Be aware of this and keep your information safe. If you use a computer that is used by others, checking "Stay logged in?" may give other people access to your account. "Stay logged in" may not work if you use your web browser in a private mode or if you have your web browser set to clear all your history and cookies when you close it. If you check the checkbox next to the words "Stay logged in?", you will be kept logged in for up to two weeks, unless you log out. If you continue having trouble, see Why am I having trouble getting into My Account? below. Check your Caps-Lock key and try again or contact your local library.Īnd you must try again. The username or password provided was not valid. If you make a mistake in either place, you will get this error message: Remember that your password is case sensitive. To log into the online catalog, you do not need any of those spaces.Įnter your password into the right box. ![]() Hint: The barcode that appears on the back of your library card or on your mini-card has spaces in it. Enter your barcode, (your library card number), without spaces, or user name in the left box. ![]() It is generally found that the close position chords in higher registers will tend to work better when bass and other chordal accompaniment is present, due to the span of notes not exceeding the octave. It is not possible to predict which chord voicing type will perform best in any given situation one should use the ear as the ultimate judge. The close position chords have a more pianistic quality, especially in high registers, due to the intervals being arranged in sequential order and fitting within an octave. The open position chords have a guitar-like sonority due to their intervallic arrangement. Two types of chord voicings are presented, these are “open position”, meaning all chord tones are sounded with some note(s) more than an octave above the lowest tone and “close position” where all tones are sounded within the space of an octave or less. The resemblance to the standard minor 7 th chord should be very clear, as only the fifth is raised one half step, or one fret in terms of the guitar. The formula for a minor 7#5 chord is as follows: 1-b3-#5-b7 or with C as its root: C, Eb, G#, Bb. ![]() The minor 7#5 chord discussed in this article is very different from the augmented formula as it has a minor 3 rd instead of a major 3rd. Another explanation is because generally when“#5” is mentioned musicians often assume an augmented chord containing a major 3 rd, 1-3-#5. This is likely due to the fact that it is not a naturally occurring chord in the major scale or any of the principal minor (harmonic, melodic) scales. The harmonic structure known as a minor 7 th #5 chord (m7#5) is a relative obscurity in modern music. ![]() KTTV FOX Good Morning LA’s Araksya Karapetyan and NBC-LA News’ Gordon Tokumatsu, along with KSEE-Fresno News’ Stefani Booroojian interviewed Hovannisian and produced impactful stories that aired several times in April. The multiple award-winning film caught the attention not only of NBCLX, but of news stations in Hovannisian’s native California. Together, they dig beneath the surface of modern-day Turkey, unearthing buried secrets, silenced stories, living resilience, and the hidden map. The film chronicles their joint odyssey trekking through the layered landscape, Scotsman determined to document the physical relics, and the Armenian-American, the stories of the people. In Turkey, Hovannisian, a granddaughter of Genocide survivors, met a lone Scottish explorer by the name of Steven Sim who had spent 30 years documenting the vanishing traces of the Armenian past. She always knew she would one day share the Armenian story on a grand scale, but it didn’t happen until she dared to venture to the forbidden lands of her ancestral past. With that, I can exhale, if just a little.”Īs a broadcast journalist, Hovannisian has spent a career producing and directing non-fiction stories for television. I believe that it will live far beyond us. “It’s filling,” she expressed, “ It’s as if the flood gates opened, and people from all over the country, Armenians and non-Armenians, poured their hearts out… expressing that the documentary hit home in ways they didn’t even know exist, made them part of the continuing story, and awakened purpose and desire to learn and do more. It’s an ideal match, and I’m thankful for that.” Hovannisian is overwhelmed by the positive reactions of viewers. Hovannisian added, “ For NBCLX to recognize that everyone should know this story, and to offer viewers three more primetime opportunities to do so, highlights the substance of the network. We are honored that she has trusted NBCLX with distributing it.” ![]() Ani Hovannisian’s documentary is compelling, unique and so important for everyone to see. “NBCLX is thrilled to once again share The Hidden Map with our audience,” said Vice President of Content Strategy Matt Goldberg, “So many people have reached out to us asking for more ways to watch the film. Standing for truth in storytelling and responding to viewer demand, the network has announced three more airings of the film over Memorial Day weekend, which also marks the 103rd anniversary of the First Republic of Armenia. The fast-growing NBC-owned network known for its innovative deep-dive approach to pressing social issues and current events ran the film six times during the weekend of April 24, 2021, coinciding with President Biden’s official recognition of the Armenian Genocide. Following a widely acclaimed television debut, Ani Hovannisian’s documentary The Hidden Map has been scheduled for encore broadcasts on NBCLX nationwide on May 28, 29 and 30, 2021. |
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